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Zytiga is a prescription drug used in combination with prednisone, for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in men. The drug works by regulating the production of androgens in the body. Zytiga was approved by the FDA for oral administration in the year 2011 and is being manufactured by Janssen Pharmaceuticals.
The active ingredient of Zytiga is Abiraterone Acetate which is an inhibitor of an enzyme known as CYP17 (17α-hydroxylase/C17,20-lyase). Within the body, abiraterone acetate is converted into abiraterone which is an androgen biosynthesis inhibitor and inhibits CYP17.
CYP17 is imperative for androgen production in the body. By inhibiting CYP17, abiraterone inhibits testosterone production, which results in increased in mineralocorticoids production. Since prostate cancer is sensitive to androgens, androgen inhibition controls the spread of cancer1.
Zytiga comes in the form of packs with a variable amount of tablets and strength. The recommended dose of Zytiga is 1000mg once daily which means for instance that 4 tablets of 250 mg of Zytiga should be taken to achieve a 1000 mg dose. This dose often considers taking it along with tablets of prednisone, often 5mg are prescribed to be taken twice daily. Always ask your doctor how exactly you should take your medication. In patients with moderate hepatic impairment, the recommended dose of Zytiga is 250mg per day.
The ideal way is to take the tablets with a little amount of water twice daily on an empty stomach. Zytiga should be taken at least 1 hour before or 2 hours after food. The tablets should be swallowed whole and should not be crushed or chewed.
Zytiga is indicated for men suffering from metastatic castration-resistant prostate cancer (mCRPC) which pertains to the stage of prostate cancer when the cancer cells have metastasized beyond the prostate gland. The cancer spreads even if the testosterone levels fall below the castration levels. The drug is meant for the patients who have received chemotherapy with docetaxel.
Following side effects have been observed with the use of Zytiga.
The following precautionary measures should be exercised with the use of Zytiga.
Note: This list is not all inclusive
Zytiga is a prescription drug used as an adjunct to prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in men.
The active ingredient of Zytiga is Abiraterone Acetate (acetyl ester of abiraterone) which is an inhibitor of CYP17. By inhibiting CYP17, abiraterone inhibits testosterone synthesis which helps control the spread of cancer.
Always store Zytiga at room temperature between 15oC to 30oC, away from direct light, heat and moisture. Keep the drug out of reach of children.
No, there is no alternative drug to Zytiga. The drug should be used exactly as prescribed by the doctor in precise dosage.
The most common dose of Zytiga is 1000mg once daily, which means that 4 tablets of Zytiga containing 250mg should be taken, along with 5mg of prednisone which is taken twice a day. Zytiga should be taken on an empty stomach, at least 1 hour before and 2 hours after food.
Zytiga is commonly prescribed along with prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for the patients who have received prior chemotherapy with docetaxel.
Metastatic castration-resistant prostate cancer (mCRPC) refers to the stage of prostate cancer when the cancer cells have metastasized beyond the prostate gland even if the testosterone levels fall below the castration levels.
If you accidentally overdose on Zytiga, report to the nearest medical facility, call your healthcare provider or call the Poison Control Center at 1-800-222-1222 right away.
If you miss a dose, skip the missed dose and take your next dose at the regular scheduled time. Do not double up your dose to “catch up”.