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Product Description

What is Depo Medrol?

Depo-Medrol is the trade name of a prescription drug containing methylprednisolone acetate as the active component. Depo-Medrol is an anti-inflammatory glucocorticoid (cortisone) for intralesional, intramuscular, soft tissue, and intraarticular injections and is available in strengths of 20mg/ml, 40mg/ml, and 80mg/ml. It is used for a variety of conditions, as determined by the doctor, for example allergic states, hematologic disorders, dermatologic diseases, and respiratory diseases. It is manufactured by a variety of pharmaceutical companies and is available in pack size of 5ml to10ml multi-dose.

Active ingredient

The active ingredient of Depo-Medrol is methylprednisolone, a synthetic form of the naturally occurring glucocorticoid (cortisone and hydrocortisone). It functions as replacement therapy in adrenocortical disorders, as it modifies the immune system in order to respond to a variety of stimuli such as inflammation.

Depo-Medrol injections are also available with Lidocaine, a popular anesthetic that can reduce pain during an injection. Read more about Depo-Medrol injections with Lidocaine here

Conditions treated

Depo-Medrol is used in the treatment of a variety of conditions, which include but are not limited to:

• Allergic condition, such as in seasonal or perennial allergic rhinitis, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, transfusion reactions, and serum sickness;
• Dermatologic diseases, such as Stevens-Johnson syndrome (erythema multiforme), mycosis fungoides, Bullous dermatitis herpetiformis, exfoliative erythroderma and pemphigus, severe;
• Ulcerative colitis;
• Blood disorders, such as pure red cell aplasia, acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia, and select cases of secondary thrombocytopenia;
• Palliative management of lymphomas and leukemias;
• Respiratory diseases;
• Renal disorders;
• Rheumatic disorders.

Generic vs brand name

There are a few generic brands of Depo-Medrol, and the generics are as effective as the brand-name medication.

Dosage information

Use your medication as directed by your healthcare professional. If you are not sure of how to, please check with your doctor.

• The initial dose varies from 4mg to 120mg, depending on the condition being treated. You doctor may prescribe you a different dose than what is listed here. Do not change your dose unless instructed to do so by your doctor.

Side effects

Depo-Medrol may exhibit some side effects, which include, but are not limited to the list below. Report any new experience or feeling occurring after the use of Depo-Medrol.

• Agitation
• Anxiety
• Blurred vision
• Decrease in the amount of urine
• Dizziness
• Fast, irregular heartbeat or pulse, slow
• Headache
• Irritability
• Mental depression
• Mood changes
• Nervousness

This is not a complete list of side effects. Should any side effects worsen, contact your doctor.

Warnings and precautions

Contraindications

• Depo-Medrol is contraindicated in patients with a history or who are hypersensitive to methylprednisolone or any of the ingredients used in the formulation.
• These preparations, when used intramuscularly, are contraindicated in idiopathic thrombocytopenic purpura.
• Methylprednisolone acetate is contraindicated for use in intrathecal administration.
• The use of methylprednisolone acetate is contraindicated in infants.
• The use of methylprednisolone acetate is contraindicated in systemic fungus infection.
  This may not be a complete list of contraindications.

Precautions

• When using multi-dose vial, it is essential to be careful not to cause contamination
• Serious neurological adverse reactions have been reported with epidural administration
• Contains benzyl alcohol which is toxic when administered locally to neural tissue
• When administered in large doses, can cause a rise in blood pressure
• Patients who are on corticosteroids are more susceptible for infections
• To be used with caution in patients who suffer from latent peptic ulcer

Drug interactions

Taking Depo-Medrol with certain drugs can either potentiate their effects in the body or nullify them. Therefore, you should know the medicines you take and always remember to tell your healthcare provider and pharmacist when you are prescribed new medicine. Some of the drugs that may interact with Depo-Medrol include:

• Aubagio (teriflunomide)
• Avelox (moxifloxacin)
• Azithromycin/trovafloxacin
• Bupropion
• Bupropion
• Gatifloxacin
• Gemifloxacin
• Gilenya (fingolimod)
• Ketoconazole
• Korlym (mifepristone)
• Smallpox vaccine
• Sparfloxacin
• Sporanox (itraconazole)
• Sporanox PulsePak (itraconazole)
• Stamaril (yellow fever vaccine)

Frequently asked questions

How to store Depo-Medrol?

• Store away from direct sunlight and heat.
• Store in the refrigerator at temperature.
• Keep out of the reach of children.

What if I overdose on Depo-Medrol?

• If you accidentally overdose on Depo-Medrol seek immediate medical advice or call the Poison Control Helpline at 1-800-222-1222.