Benadryl Extra Strength Nighttime® for Pain and Allergy Relief

What Benadryl Extra Strength Nighttime® Is and How It Works

Benadryl Extra Strength Nighttime® is an over-the-counter combination of acetaminophen and diphenhydramine HCl. It relieves pain and reduces allergy or cold symptoms at night, and the antihistamine may help with sleep. Many shoppers compare benadryl extra strength nighttime without insurance pricing when planning monthly budgets. This product is taken by mouth and is intended for short-term, nighttime use.

Acetaminophen is a pain reliever and fever reducer. It works in the central nervous system to reduce pain signals. Diphenhydramine is a first-generation antihistamine. It blocks H1 receptors to reduce histamine symptoms such as sneezing, runny nose, and itch. It also crosses the blood-brain barrier and can cause drowsiness, which supports nighttime rest.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Orders are processed under Canadian pharmacy standards, and prescriptions are reviewed by licensed pharmacists before dispensing when required. We offer brand and generic medicines at Canadian prices and also carry OTC health products.

We source through licensed and vetted partner pharmacies so you receive authentic brand medications and a wide selection at affordable prices.

Dosage and Usage

Use this product exactly as shown on the package label. It is for adults and children 12 years and older unless the label states otherwise.

• Read the Drug Facts label to confirm the active ingredients: acetaminophen and diphenhydramine HCl.
• Take the dose at bedtime when nighttime symptoms occur.
• Swallow tablets or caplets whole with water. Do not crush or chew unless the label allows it.
• Follow the package dosing schedule. Do not exceed the maximum stated on the label.
• Do not use with other products that contain acetaminophen.
• Avoid alcohol, driving, or operating machinery due to drowsiness.
• If a planned dose is missed, take it at the next bedtime if still needed. Do not double up.

Short-term use is preferred. If pain, fever, or allergy symptoms last more than a few days, contact a healthcare professional. People with liver disease, chronic breathing problems, glaucoma, or prostate enlargement should seek medical advice before use.

• Storage: store at 15–25 °C (59–77 °F), away from heat and moisture.
• Keep in the original packaging and out of reach of children.
• Travel: pack in carry-on luggage, in the original labeled container.
• Do not leave in a hot car or direct sunlight.

Benefits and Savings

This nighttime formula offers dual relief. Acetaminophen handles headaches, muscle aches, and minor pain, while diphenhydramine reduces allergy and cold symptoms like runny nose and sneezing. The sedating antihistamine can help you fall asleep when symptoms disrupt rest.

Ordering from YouDrugstore is simple online or by phone during posted hours. Friendly customer-service chat is available to help with account or order questions, and pharmacists can address medication questions.

Buying from Canada often brings meaningful savings. Many customers see 60–80% lower costs compared with typical U.S. prices, including those shopping without insurance. Multi-pack options may reduce the per-month cost.

Side Effects and Safety

Most people tolerate this product well at label doses. Drowsiness is expected. Some effects are more likely in older adults.

• Common: drowsiness, dizziness, dry mouth, dry eyes, blurred vision.
• Gastrointestinal: nausea, constipation, stomach discomfort.
• Urinary: difficulty starting urination, especially with prostate enlargement.
• Neurologic: impaired coordination or confusion, especially in seniors.
• Allergic: rash or itching.
• Liver risk: nausea, upper right abdominal pain, dark urine, yellowing of skin or eyes (possible acetaminophen toxicity).

Stop use and seek medical help right away for severe drowsiness, confusion, fainting, irregular heartbeat, severe allergic reaction, or signs of liver injury. Do not combine with other products that contain acetaminophen. Avoid alcohol and recreational sedatives. Speak with a healthcare professional before use if taking benzodiazepines, opioids, other antihistamines, sleep aids, MAOIs, or medications for depression, anxiety, seizures, or Parkinson’s disease.

People with glaucoma, asthma or COPD, thyroid disease, cardiovascular disease, liver disease, or difficulty urinating should ask a healthcare professional before use. This product is not intended for children under the age stated on the package label.

Onset Time

Diphenhydramine usually begins to cause drowsiness within 30 to 60 minutes. Pain relief from acetaminophen typically starts within 30 to 60 minutes as well. Plan dosing to allow enough time before bedtime. Individual response can vary with age, other medications, and whether it is taken with food.

Compare With Alternatives

Several nighttime and allergy options exist. Tylenol PM products also combine acetaminophen with diphenhydramine for nighttime pain. Plain diphenhydramine (such as sleep aids or allergy capsules) helps with allergy symptoms and sleep but does not treat pain. Doxylamine (found in some sleep tablets) is another sedating antihistamine option for occasional insomnia.

For pain linked with inflammation, some people consider ibuprofen plus diphenhydramine combinations at night. These may help when swelling contributes to discomfort, but they can irritate the stomach and are not right for everyone. Daytime non-drowsy antihistamines manage allergies without sedation, but they will not help with sleep.

Combination Therapy

Do not use with other acetaminophen-containing products to avoid accidental overdose. Avoid layering with other sedating medicines unless a healthcare professional approves. People often pair nighttime dosing with non-drug measures such as a dark, cool bedroom, a consistent sleep schedule, and limited late caffeine. For allergy triggers, nasal saline rinses and evening showering may help reduce pollen exposure during sleep.

Patient Suitability and Cost-Saving Tips

This product suits adults and teens who need nighttime pain and allergy relief and who can tolerate sedating antihistamines. It may not be appropriate for older adults at risk of confusion or falls, or for people with glaucoma, significant liver disease, severe breathing problems, or urinary retention. A healthcare professional can help assess fit and timing with other therapies.

To lower costs, consider brand versus generic options, and compare pack sizes. Multi-month supplies may reduce the per-unit price, and reorder reminders help you avoid last-minute purchases. See current deals and bulk options on our benadryl extra strength nighttime coupon page. This can be helpful for those paying the benadryl extra strength nighttime cash price.

You may place orders online at YouDrugstore, and our customer-service chat is available during posted office hours for account or shipping questions. If you have medication questions, a licensed pharmacist can help.

Authoritative Sources

For detailed product and regulatory information, see the manufacturer and government resources below:

• Benadryl Canada product information
• Health Canada Drug Product Database

Order from YouDrugstore for Canadian pricing and careful dispensing. We ship to the U.S. with prompt, express, cold-chain shipping options when needed, and we pack orders securely for transit.

This content supports safe shopping and is not a substitute for professional medical advice. Always follow the package Drug Facts and ask a healthcare professional about personal medical conditions, allergies, or medication interactions.