Domperidone Tablets for Nausea and Gastroparesis

What Domperidone Is and How It Works

Domperidone is a dopamine D2-receptor blocker that helps relieve nausea, vomiting, and symptoms of gastroparesis. This page on YouDrugstore is a helpful domperidone online pharmacy resource for patients with a valid prescription. Many people also look for domperidone without insurance when paying cash. Domperidone is usually supplied as 10 mg oral tablets taken before meals.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba that meets Canadian pharmacy standards, and our pharmacists review prescriptions before dispensing. You can order online, and customer-service chat is available during posted office hours. We also source through licensed, vetted partner pharmacies worldwide to ensure authentic brands and a wide selection at affordable prices.

Domperidone improves stomach emptying and reduces nausea by blocking dopamine receptors in the gut. This increases gastrointestinal motility and raises the lower esophageal sphincter tone, which may ease reflux-related symptoms. It does not cross the blood–brain barrier well, so it tends to cause less sedation than some antiemetics.

Dosage and Usage

Follow the prescriber’s directions on dose and duration. Domperidone use should be at the lowest effective dose and for the shortest possible time due to cardiac risk.

• Typical adult dose: 10 mg by mouth three times daily, 15–30 minutes before meals.
• Some patients take an optional bedtime dose if night symptoms are present.
• Do not exceed 30 mg per day unless a prescriber directs otherwise.
• People with kidney problems may need less frequent dosing.
• Use in children is restricted and should follow specialist guidance.

Titration is usually limited. If symptoms improve, prescribers may reduce dose or stop therapy after a short course. Domperidone is sometimes used off-label for lactation. That use requires close supervision because of cardiac and hormonal risks.

• Missed dose: take the next scheduled dose. Do not double up.
• Avoid grapefruit or strong CYP3A4 inhibitors with domperidone unless the prescriber approves.

• Storage: store tablets at room temperature in a dry place. Keep in the original bottle.
• Travel: keep tablets in your carry-on with the prescription label. Use a pill organizer if helpful, and bring enough for your trip.
• Disposal: follow local guidance or return unused tablets to a pharmacy take-back program.

Benefits and Savings

Domperidone can reduce nausea and vomiting and may help post-meal fullness, bloating, and early satiety linked with delayed gastric emptying. Many patients prefer it because it is less sedating than some alternatives. Tablets are small and simple to take before meals.

Buying from a licensed Canadian pharmacy can mean large savings. Typical customers see 60–80% lower prices than common US retail pricing. Many people pay out of pocket without insurance for domperidone, so predictable pricing and clear product information matter. You can reorder easily and request reminder emails before refills are due.

Side Effects and Safety

Most side effects are mild and often improve after dose adjustment or short-term use. Serious cardiac risks can occur, especially at higher doses or with interacting drugs.

• Common: dry mouth, headache, stomach cramps, constipation or diarrhea, dizziness.
• Hormonal: increased prolactin may cause breast tenderness, milk discharge, or menstrual irregularities; rare gynecomastia in males.
• Serious: palpitations, fainting, chest pain, shortness of breath, or fast or irregular heartbeat. Seek urgent care if these occur.

Domperidone can prolong the QT interval and may increase the risk of serious ventricular arrhythmias. Risk rises with higher doses, in people over 60, with electrolyte problems, congenital long-QT, structural heart disease, or when combined with QT-prolonging or strong CYP3A4-inhibiting drugs.

Drugs that may raise risk include certain macrolide antibiotics (for example, clarithromycin, erythromycin), azole antifungals (for example, ketoconazole), some calcium channel blockers (for example, verapamil, diltiazem), amiodarone, and many others. Alcohol may worsen dizziness. Discuss current medications and health history with the prescriber before starting domperidone.

Use is often avoided in moderate to severe liver disease. Report any sustained abdominal pain, black stools, jaundice, swelling, or severe dizziness. Pregnant or breastfeeding individuals should review risks and benefits with their clinician.

Onset Time

Nausea improvement can begin within 30 to 60 minutes after a dose. For gastroparesis symptoms, several days of scheduled dosing may be needed to see steady benefit. Off-label lactation effects, when monitored by a clinician, may take longer and vary by individual.

Compare With Alternatives

Several medicines are used for nausea and gastroparesis. Each option has distinct benefits and risks.

Ondansetron is a 5-HT3 antagonist that helps many causes of nausea, including postoperative and chemotherapy-induced nausea. It does not increase gastrointestinal motility. Common effects include constipation and headache. QT prolongation can occur, especially at higher intravenous doses or with risk factors.

Metoclopramide is both antiemetic and prokinetic. It crosses the blood–brain barrier and can cause drowsiness, restlessness, and, with longer use, movement disorders such as tardive dyskinesia. Some clinicians choose domperidone when a prokinetic effect is needed but central nervous system side effects are a concern.

Erythromycin can stimulate motilin receptors and speed gastric emptying, but tachyphylaxis often develops within days to weeks. It also has significant drug interactions and QT risk. The best choice depends on diagnosis, comorbidities, concurrent medications, and goals of therapy.

Combination Therapy

Domperidone may be used with non-drug measures such as smaller meals, reduced fat intake, hydration, and electrolyte replacement. Some patients use it alongside acid suppression if reflux is present. Avoid combining domperidone with other QT-prolonging or strong CYP3A4-inhibiting drugs unless a prescriber has weighed the risks. For lactation support, clinicians often pair non-pharmacologic strategies with any medication plan and monitor closely.

Patient Suitability and Cost-Saving Tips

People with nausea, functional dyspepsia, or delayed gastric emptying may be considered for domperidone after evaluation. Those with known long-QT, significant heart disease, severe liver impairment, or electrolyte disturbances often need a different plan. Elderly patients and those on multiple medications require extra review. For symptom context, see our condition pages for Nausea, Vomiting, and Indigestion.

To reduce costs, consider generic tablets and a multi-month quantity if appropriate. Larger fills can lower the per-month cost and reduce shipping fees. Set up reorder reminders so you do not run short. Many customers paying domperidone without insurance appreciate clear invoices and consistent pricing. Our team can help with order status and product questions during office hours.

Authoritative Sources

See the FDA’s overview, Information About Domperidone, for US-specific safety information on the FDA website. Review Health Canada’s Drug Product Database for Canadian entries and safety details in the DPD. For a branded reference, consult Janssen Canada’s Motilium product information if available on Janssen Canada.

YouDrugstore offers caring service, Canadian pharmacy oversight, and fair pricing. Order online or by phone, and our customer-service chat is ready during posted hours. We ship to the US with prompt, express, cold-chain shipping when needed.

This content is for general information only and does not replace medical advice. Always follow your prescriber’s directions and the patient leaflet that comes with your medication.