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APO-Duloxetine is the trade name of a prescription drug containing Duloxetine as the active component a norepinephrine and serotonin reuptake inhibitor. APO-Duloxetine is a delayed release capsule of duloxetine used in the treatment of generalized anxiety disorders, chronic musculoskeletal pain, diabetic peripheral neuropathic pain and major depressive disorder. APO-Duloxetine is manufactured by APOTEX Pharmaceuticals and is available as oral capsules (blue/white in color) with the litters APO-D30 printed on, it is available in a pack size of 30 capsules.
Duloxetine is the active ingredient of APO-duloxetine, the exact method by which duloxetine function to treat patients is unknown, however it is believed to function by triggering changes in the activities of norepinephrine and serotonin which and both chemicals in the brain. Norepinephrine is the chemical in the body that acts mainly in the brainstem and plays a major role in a person’s flight or fight response, how someone response to moods, pain, thinking, blood pressure and movement. Serotonin on the other hand is the brain chemical that is function in mood regulation pain perception etc.
APO-Duloxetine is used for the treatment of:
There are a few generic brands for the oral capsules of APO-Duloxetine. APO-Duloxetine is a generics and is very much effective as the originator.
The recommended dosages of duloxetine based on the different conditions treated by it is as follows;
For major depressive disorder (maximum dose of 120 mg per day)
Generalized anxiety disorder and Diabetic peripheral neuropathic pain (maximum dose of 120 mg per day)
Chronic Musculoskeletal
Note: the doctor may be required to prescribe doses that differ from the above dosages, do not change your dose or take the medication contrary to the doctor’s directions.
Some of the side effects of APO-Duloxetine include.
These may not be all the side effects.
Serotonin syndrome: MAOIs should not be used in conjunction with duloxetine capsules or within the five day period after stopping treatment with duloxetine.
Do not use APO-Duloxetine delayed release capsules in patients being treated with intravenous methylene blue or linezolid
The use of duloxetine associated with hepatic failure in patients treated with duloxetine, treatment should be discontinued immediately in patients that show signs of liver dysfunction or jaundice.
APO-duloxetine should not be administered to patients with liver disease or substantial alcohol use.
The use of duloxetine may lead to serotonin syndrome
Duloxetine may cause orthostatic hypotension in patients.
The use of duloxetine may lead to an increase risk of abnormal bleeding with might also increase with the use of NSAIDs.
Skin reactions such as erythema multiforme, Stevens Johnson syndrome may occur with duloxetine use.
The use of duloxetine may lead to the activation of hypomania or mania.
Duloxetine should be use with caution in patients with a history of seizures.
Blood pressure of the patient should be monitored prior to and after initiating treatment.
Urinary Retention and Hesitation.
Hyponatremia.
Taking APO-Duloxetine with certain drugs can either potentiate their effects in the body or nullify them, it may affect the manner in which these drugs work or vice versa. Therefore you should know the medicines you take and always remember to tell your healthcare provider and pharmacist when you are prescribed new medicine. Below are some examples of medicines that may interact with APO-Duloxetine when used together.
This list is not complete so always find out with your doctor if the current medication you taking can interfere with APO-Duloxetine.
This list is not all inclusive and you should ask your pharmacist or doctor if APO-Duloxetine interacts with any medication you are taking
APO-Duloxetine is an FDA approved drug for use in the treatment of:
The exact method by which duloxetine function to treat patients is unknown, however it is believed to function by triggering changes in the activities of norepinephrine and serotonin which and both chemicals in the brain.
Store away from direct sunlight and heat.
Store at room temperature between 15˚C-30˚C.
Do not store in a humid place (bathroom).
Keep in a well closed container.
Keep out of the reach of children.
Yes, there are a few generic brands for the oral capsules of APO-Duloxetine. APO-Duloxetine is a generic and it is much as effective as the originator. An alternative brand medication is Cymbalta.
NO it is not called by a different name.
For major depressive disorder (maximum dose of 120 mg per day)
The starting dose is 40-60mg per day.
Acute treatments, it can be issued as 40mg per day in divided doses to 60 once daily dose or divided doses.
Maintenance dose is 60 mg per day.
Generalized anxiety disorder and Diabetic peripheral neuropathic pain (maximum dose of 120 mg per day)
The recommended dose for adults is 60 mg per day
Chronic Musculoskeletal
The starting dose is 30 mg per day and can be increased to a maximum dose of 60 mg per day.
Take the capsules with or without food
Swallow capsule whole and do not chew or crush, and do not open capsule.
Note: your doctor might recommend a dose different from the above dose, do not try and change the directions issued to you by the doctor.
For the treatment of:
If you accidentally overdose on APO-Duloxetine, seek immediate medical advice or call the Poison Helpline at 1-800-222-1222.
Symptoms of over dose may include, coma, hypotension serotonin syndrome, syncope, tachycardia, hypertension, seizures, vomiting and somnolence.
This list is not complete therefore you should ask your pharmacist or doctor about possible signs and symptoms of over dosage.
Take a dose as soon as you remember, however if you remember just an hour or two before the next dose, only take one dose. Never try to double up on the doses.