What is Cialis?
Known generically as tadalafil, Cialis is a prescription drug indicated for the treatment of erectile dysfunction, benign prostatic hyperplasia (BPH), and BPH with erectile dysfunction. It was approved by the FDA in February of 2003 as a first-line treatment for these disorders, making it the third Phosphodiesterase type 5 (PDE5) inhibitor to be marketed worldwide, next to Pfizer’s Viagra and Bayer’s Levitra. While it is generally well tolerated by most men, commonly reported side effects include headache, indigestion, flushing, and stuffy nose. Self-limiting muscle pain (myalgia), back pain, and abnormal vision have also been reported with Tadalafil use.
How Does it Work?
Cialis works by inhibiting PDE5, an enzyme that specifically degrades cyclic guanosine monophosphate, or cGMP. The process of erection is governed by cGMP activity, which relaxes the smooth muscle cells to increase blood supply to the penile erectile tissues.
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What exactly does Erectile Dysfunction (ED) mean?
Erectile dysfunction (ED), that is, difficulty in getting or maintaining an erection that interferes with sexual intimacy, until 15 years ago, was in the closet, labeled “impotence.” Then came along a drug called sildenafil, which was tested by Pfizer to treat heart disease symptoms, like angina. It flunked the tests, but when men started chortling about all the erections they were experiencing while enrolled in the study, sildenafil was taken off the shelf and earned FDA approval for erectile dysfunction.
Why treat ED?
Anyone who asks this has never had it. 100 million men worldwide do, however. Intercourse is so important that many religious and civil definitions of marriage use it as the criterion that consummation of marriage. This is somewhat an intrusion of privacy, because there are many asexual unions that work fine. But the majority of unions that suffer ED do not work fine. They struggle.
It takes two t ...