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Treatment of Schizophrenics with Antipsychotics

Treatment of Schizophrenics with Antipsychotics
Schizophrenia is a mental illness that is catastrophic in respect to its debilitating features. It has “positive” symptoms of hallucinations, delusions, and disorganized thinking; “negative” symptoms of withdrawal; cognitive symptoms of impaired memory, learning, understanding, and problem-solving; and emotional symptoms that include depression, anxiety, and suicidal tendencies. What is the logic in treating schizophrenia? Since it is a genetic disorder that involves variations in neurotransmitters, with the most important one being dopamine, medications that alter dopamine as well as glutamate, GABA, and acetylcholine are the cornerstone of therapy. Messing with neurotransmitters is serious business, which means that medications that manipulate them offer great promise as well as serious side effects. Nevertheless, no one wants to go back to the days before 1950 when psychiatric facilities were nothing more than prisons. When Thorazine (chlorp ...

What is Nortriptyline 25mg Used For?

What is Nortriptyline 25mg Used For?
Nortriptyline 25mg is used to treat mental or mood problems such as depression. It is being marketed under the brand names Pamelor and Aventyl. This medication is a tricyclic antidepressant, specifically of dibenzocycloheptene type, and is the active metabolite of the tertiary amine‚ÄĒamitriptyline. Tricyclic antidepressants work by inhibiting the reabsorption of the biogenic amine neurotransmitters: norepinephrine (NE) and serotonin (5HT). Tertiary amines inhibit the reuptake of both neurotransmitters, but secondary amines like nortriptyline are more selective of inhibiting NE over 5HT. Tricyclic antidepressants (TCA) are rarely used as first-line or even second-line treatment for depression because of its extensive side effect profile and high overdose risk. However, it is still one of the most effective pharmacological therapies for severe depression or major depressive disorder of melancholic type, demonstrating greater efficacy over selective serotonin reuptake inh ...

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