General Information About Avandaryl

Avandaryl is the brand name of a prescription drug containing a combination of glimepiride and rosiglitazone. It is indicated for the treatment of type 2 diabetes. Glimepiride belongs to a class of drugs known as sulfonylureas whereas rosiglitazone belongs to a class known as thiazolidinediones. The reduction of blood sugar levels delays or prevents the occurrence of further complications such as heart attack, stroke, kidney failure, nerve problems, loss of limbs, and blindness. This medication is usually recommended for people who have not been able to achieve proper control by using either of these ingredients alone or by using other anti-diabetic medication. It is highly recommended to use this medication along with a proper diet and regular exercise.

It should not be used with insulin as this may lead to an increased risk of serious heart problems.

Avandaryl is manufactured and marketed in Canada by GlaxoSmithKline

Active ingredients

The active ingredients in this medication are glimepiride and rosiglitazone.

Glimepiride belongs to a class of drugs known as sulfonylureas. It has a long duration of action and it is thought to work by helping the body produce more insulin, as well as increasing the sensitivity to peripheral tissues to insulin.

Rosiglitazone belongs to the thiazolidinedione class of drugs. It works by activating the intracellular receptors of the peroxisome proliferator-activator receptors class. It appears to have an effect on insulin resistance, as well as an anti-inflammatory effect. It helps insulin to work more effectively allowing the cells to take up more sugar from the blood.

Conditions treated

This medication may also be used for other conditions not mentioned above.


Dosage information

Always take your medication exactly as instructed by the doctor. The dosage given by the doctor may differ from the ones indicated here. Please do not try and alter your dosage in order to change the treatment outcome without consulting your doctor. There are many factors that are considered by the doctor when determining the dosage for your specific case, such as the patient profile (age, body weight, other medication and other medical conditions), the condition being treated, and response to treatment.

Take the tablet once a day with the very first meal of the day or as otherwise prescribed by the doctor. The maximum daily dose should be 8mg rosiglitazone and 4mg glimepiride.

Regular exercise and a good diet will help the medication work better.

Take the medication regularly and as directed in order to get the full benefit of the drug. It may take a couple of days for the blood sugar to start dropping and up to 2 to 3 months to get the full benefit of the drug.

The doctor may need check your blood sugar levels regularly to see if the medication is working properly.

Side effects

This medication may cause side effects. If the effects cannot be handled or tolerated, you should immediately report to your doctor.

You should seek immediate medical attention if you have a serious drug reaction to this medication such as: difficulty breathing, severe dizziness, and swelling of face/throat/tongue.

This is not a complete list of side effects that may occur after using this medication.

Warnings and precautions

Always inform your doctor about any known history of allergies to medication, especially if you have reacted to any products that contain either glimepiride or rosiglitazone, or any other drugs of the same class before. The use of this medication may be affected by or may affect certain chronic or current conditions such as liver damage, blood disorders, pituitary gland disorder, swelling/edema, kidney failure/damage, glucose-6-phosphate dehydrogenase deficiency, eye problems caused by diabetes and hypoglycemia. If you currently have or if you have a history of any of the above, you should speak to your doctor about how this medication may affect you before you start using it.

The use of Avandaryl on its own does not cause hypoglycemia. However, this may happen when used in combination with other anti-diabetic medication, if you drink alcohol or if you don’t eat regularly. Low blood sugar may occur, especially if such use is not accompanied by a proper diet and exercise regimen. Eat meals on a regular schedule while taking this medication in order to avoid having low sugar levels.

In some rare cases, rosiglitazone may cause liver problems, the symptoms of which are yellowing of the eyes and skin, dark urine, persistent nausea and vomiting. If you happen to experience any of these, you should seek immediate medical attention.

If you are a woman of childbearing age, you should speak to your doctor about how the use of this medication may affect you. It has been known to cause significant changes in the menstrual cycle of women and may lead to pregnancy. A reliable form of contraception may be recommended.

Rosiglitazone is associated with weight gain due to fluid retention. This may pose a serious problem especially for people who already have chronic conditions such as heart problems.

The use of this medication increases the risk of getting bone fractures.


Drug interactions

Using this medication together with certain drugs may change the effects of one or the other. It is important to notify your doctor and/or pharmacist of any medication that you currently are taking or intend to use concurrently with Avandaryl. This includes medication obtained with or without a prescription. Some of the medication that would interact with Avandaryl include, but are not limited to:

This is not a complete list of drugs or substances that may interact with Avandaryl. You should report any side effects or feeling of uneasiness that may result from using this medication together with another drug/substance.

The medication listed above may interact with Avandaryl to varying degrees. The doctor would use his discretion to do a risk/benefit analysis of using the drugs involved before making a decision. Some of the interactions require no medical attention and will wear off as soon as the drugs have left the system.

Frequently asked questions

How to store it

Is there an alternative generic brand to Avandaryl?

There is no generic alternative for this medication.

What if I overdose on Avandaryl?

Seek immediate medical attention or call the Poison Control Helpline at 1-800-222-1222. Call even if there are no symptoms of overdose.

What if I miss a dose of Avandaryl?

Take the missed dose as soon as you remember. If the time is closer to when you need to take the next one, skip the missed dose. Do not double up on a dose to make up for a missed one or call your doctor if you are not sure.