Bonefos 400mg
Our best price: $276.40 USD per pack
*Maximum: 90-day supply  Maximum 90-day supply
Please note:

Due to policy restrictions and health regulations, can only dispense a maximum 90-day (3 month) supply of your medication based on a valid prescription. A valid prescription must be written and signed by a licensed physician and must have a prescription date that is no more than one year (365 days) old. All new prescriptions are verified with a signing physician.

If you place an order that exceeds a 90-day (3 month) supply of your medication, YouDrugstore will adjust your order to conform to policy restrictions. This adjustment will be confirmed with you before your order is processed.

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Product type:
Active Ingredient(s):
clodronate disodium
400 mg
Pack Size:
120 capsule(s)
Rhone-Poulenc Rorer

How to order

You just need to add your medication to your cart in this page, submit your mailing information and payment details. We will ship your order directly to your home for a cheap cost in shipping or even FREE. Learn how to get free shipping here.

You need to have a valid prescription to buy this medication. Uploading your prescription is easy and can always get help from our expert customer representatives by calling in. You can ask your doctor to fax us your prescription directly to speed up the process. Check out our contact information here.

Why Buy From Us

We,, are a legitimate pharmacy in Canada and authorized to sell medication online. That means you can get the same price our regular customers pay when they walk into our pharmacy in Canada. We are in good standing with regulatory agencies in Canada such as the Manitoba International Pharmacists Association (MIPA) and the Canadian International Pharmacy Association (CIPA). Learn more about our Certifications and Accreditations here.

General Information About Bonefos

Bonefos is the brand name of a prescription drug containing clodronate as the active ingredient. Clodronate belongs to a group of medications called bisphosphonates. This medication is used to prevent the loss of calcium from the bones or high blood calcium levels, to maintain normal blood calcium levels, and to help manage bone diseases associated with cancer. Bonefos is manufactured and marketed by Rhone-Poulenc Rorer.

This medication is also known under the following names in the USA and Canada:

Brand names: Bonefos

Generic names: Clodronate Disodium

Active ingredients

The active ingredient in Bonefos is clodronate, which works by interfering with certain chemicals in the body to prevent the loss of calcium from the bones.

Conditions treated

Bonefos 400mg is used for the treatment and management of:

  • Calcium loss from bones;
  • Normal blood calcium levels;
  • Bone diseases associated with bone cancer.

Dosage information

Make sure to always take your medication exactly as instructed by the doctor. The dosage given by the doctor may differ from the ones indicated below. Please do not try and alter your dosage in order to change treatment outcome without consulting with the doctor. Your doctor takes into consideration several factors such as age, body weight, other medication and other medical conditions before determining the dosage specific for your case.

  • The capsules (Bonefos) should be swallowed whole with plain water.
  • The usual recommended dose varies based on different conditions and treatment goals. The dose generally ranges from 1,600mg to 3,200mg best taken on an empty stomach with a glass of water as a single dose or in divided doses.

Do not take Bonefos with milk because it decreases the amount of the medication absorbed from the body.

The doctor may prescribe doses that are different from the recommended doses above. You should not change your dose without consulting your doctor.

Side effects

Bonefos may exhibit some level of side effects. If the side effects are intolerable, see your doctor or pharmacist. Side effects include, but are not limited to:

  • Diarrhea;
  • Loss of appetite;
  • Nausea;
  • Stomach pain;

Talk to your doctor and seek immediate medical attention if any of the following occur:

  • Difficulty breathing, wheezing;
  • Mouth pain;
  • Muscle cramps in the hands, arms, feet, legs, or face;
  • Skin rash and hives;
  • Swelling;
  • Unusual tiredness or weakness.

This may not be a complete list of side effects.

Warnings and precautions

It is important to inform your doctor of any known allergies that you may have to medications, especially if you have reacted to any fungal medications before. Some medical conditions may affect or may be affected by this medication. Tell your doctor of any current of chronic conditions that you may have before you start using Bonefos.

  • Talk to your doctor before taking Bonefos capsules if you any form of kidney problems or impairments;
  • Talk to your doctor before taking Bonefos capsules if you suffer from or have had swelling, numbness of the jaw, pain, a heavy jaw feeling, or if you have lost teeth;
  • Tell your dentist that you are being treated with this medication before undergoing any dental procedures;
  • Talk to your doctor if you suffer from low calcium levels because clodronate may cause low calcium levels;

Please note the safe and effective use in children has not been established. As well, the safe and effective use of Bonefos during pregnancy and breastfeeding has not been established; therefore, use should only be made if the benefits outweigh the risk.

Talk to your doctor and/or pharmacist about other possible precautions and warnings.


  • The use of Bonefos is contraindicated in patients who are hypersensitive to clodronate or any of the excipients used in the formulation.

Drug interactions

The use of Bonefos may cause some interactions when used concurrently with certain medications. This sometimes may lead to bad effects in the body and affect the functionality of both medications.

  • Aminoglycosides (e.g., gentamicin, tobramycin)
  • Bisphosphonates
  • Calcitonin
  • Calcium-containing intravenous solutions (e.g., ringer's solution)
  • Corticosteroids (e.g., prednisone)
  • Dietary supplements containing calcium, iron, magnesium, or aluminum
  • Loop diuretics (e.g., furosemide)
  • Mithramycin
  • Diclofenac
  • Ibuprofen
  • Naproxen
  • Ketoprofen
  • Phosphate supplements

Inform your doctor of all medications being taken, including non-prescription supplements.

Frequently asked questions

How to store Bonefos

  • Store away from direct sunlight and heat.
  • Store at room temperature.
  • Do not store in a humid place (bathroom).
  • Keep out of the reach of children.

Is there an alternative generic brand to Bonefos?

Bonefos is available as a generic medication called clodronate disodium.

What if I overdose on Bonefos?

Seek emergency care immediately or call the Poison Control Helpline at 1-800-222-1222 if you think you have accidentally overdosed on Bonefos. If you do not display any adverse reactions, it is still important to report to a medical professional.

What if I miss a dose of Bonefos?

Take a dose as soon as you remember missing it. If it is almost time for the next dose, skip the missed dose and continue with the next dose as usual. Never double up on doses.

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