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Zytram Xl 150mg
Our best price: $114.19 USD per pack
*Maximum: 90-day supply  Maximum 90-day supply
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Product type:
Active Ingredient(s):
150 mg
Pack Size:
60 tablet(s)
Zytram Xl
Purdue Pharma
Country of Origin:

Product Information - Zytram

What is Zytram?

Zytram is the trade name for a drug manufactured and marketed as an extended release formulation of different strengths: XL 150 mg, 200 mg, 300mg, and 400mg. It is a synthetic opioid used to treat moderate-to-severe pain. It has also been used as an alternative in patients who cannot take non-steroidal anti-inflammatories (NSAIDs). However, it should be noted that tramadol has no known anti-inflammatory properties. Hence, they can be used together with NSAIDs for pain management in inflammatory conditions, but not as a replacement for anti-inflammatories.

Active ingredients

Tramadol hydrochloride acts as a morphine receptor agonist and also a serotonin-norepinephrine reuptake inhibitor. This means that it has similar pharmacological profile as morphine as it mimics its activity. This is why tramadol on its own has a self-synergistic type analgesic action. The maximum recommended daily dose is a total of 400mg. The extended-release tablets combat the increase and decrease of drug plasma levels often found with the immediate release formulation since tramadol has a half-life of approximately 5 to 6 hours. 

Conditions treated 

Zytram is mainly used to treat moderate-to-severe pain. It can be used chronically for pain management in cancer patients, in people suffering from lower back pain, and many forms of orthopedic or neuropathic pain.

Generic and brand name

Zytram is the brand name for the drug tramadol hydrochloride. There are other brands and generics available on the market. They may be available in different forms such as immediate- and prolonged-release tablets.

Indications and dosage

Zytram XL is a prolonged-release dose formulation available in several strengths: 150mg, 200mg, 300mg, and 400mg. The different strengths are prescribed depending on the severity of the pain and/or condition being treated. This would be determined by the prescribing physician.

Extended release tablets are meant to be taken whole and not crushed or chewed. This is because they are designed to be released into the body slowly over a period of 12 hours. Swallow the tablet whole with a glass of water. Do not crush or break the tablet.

Always take your tablets exactly as recommended by your prescribing physician. The dose is usually meant to be repeated every 12 hours. Contact your doctor if you are not sure of the correct dose.

Medication identification

150mg: An oval controlled release tablet, which is film-coated and white in color. It is marked ‘T150’ on one side and contains 150mg of Tramadol.

200mg: An oval controlled release tablet, which is film-coated and white in color. It is marked ‘T200’ on one side and contains 200mg of Tramadol.

300mg: An oval controlled release tablet, which is film-coated and white in color. It is marked ‘T300’ on one side and contains 300mg of Tramadol.

400mg: An oval controlled release tablet, which is film-coated and white in color. It is marked ‘T400’ on one side and contains 400mg of Tramadol.

Each of the above listed tablets also contains non-medicinal excipients, namely lactose magnesium stearate, hypromellose, talc, polyethylene glycol, hydrogenated vegetable oil, and titanium dioxide.

Side effects

If the effects are adverse and cannot be handled or tolerated, you should immediately report to your doctor.

  • Constipation
  • Nausea and vomiting
  • Stomach pain
  • Bloating and gas
  • Diarrhea
  • Loss of appetite
  • Headache
  • Dizziness
  • Dry mouth
  • Heartburn

Warnings and precautions

Tell your doctor if you are currently taking any other medication and if you have any known chronic conditions. The excretion of tramadol is usually delayed in elderly patients. A dose adjustment may be required if this applies to you.

The central nervous system (CNS) effects of tramadol such as blurred vision, dizziness, and drowsiness are increased by alcohol.

Tramadol may affect your ability to drive, operate heavy machinery, and disturb general coordination and balance. Do not drive while on Zytram until you are sure of how it affects you.

Zytram contains lactose as one of its excipients. Please inform your doctor if you are intolerant to lactose.

The use of tramadol generally contraindicated in the following cases:

  • Hypersensitivity to any other the ingredients;
  • Children under the age of 12;
  • History of severe liver and kidney disease;
  • Pregnancy and breastfeeding;
  • History of addiction or dependence on medication;
  • Serotonin syndrome;
  • History of seizures;
  • History of asthma or COPD.

Drug interactions

Using Zytram together with certain drugs may change the effects of one or the other. It is important to notify your doctor of any medication that you currently are taking or intend to use concurrently with Zytram. This includes medication obtained with or without a prescription.

  • Amphetamines (e.g., dextroamphetamine, phentermine)
  • Antipsychotics (e.g., chlorpromazine, haloperidol, quetiapine, olanzapine, risperidone)
  • Barbiturates (e.g., phenobarbital)
  • Calcium channel blockers (e.g., diltiazem, nifedipine, verapamil)
  • Dabrafenib
  • Ergot derivatives (e.g., dihydroergotamine, ergonovine, ergotamine, methylergonovine)
  • HIV non-nucleoside reverse transcriptase inhibitors (e.g., efavirenz, etravirine, nevirapine)
  • Imatinib
  • Lithium
  • Macrolide antibiotics (e.g., clarithromycin, erythromycin, telithromycin)
  • Nefazodone
  • Opioids (e.g., morphine, codeine, oxycodone)
  • Phenobarbital
  • Quinidine
  • Rifampin
  • Selective serotonin reuptake inhibitors (SSRIs; e.g., paroxetine, fluoxetine, citalopram)
  • John's Wort
  • Tricyclic antidepressants (TCAs; e.g., amitriptyline, imipramine)
  • Warfarin

The medication listed above may interact with tramadol to varying degrees. This is not a complete list of interactions.

How to store

  • Keep out of the reach and sight of children.
  • Do not store above 30˚C.
  • Store in a cool, dry place and away from direct sunlight.
  • Keep in a closed container.
  • Use before the expiry date that is marked on the box or the blister. The expiry date is usually the last day of the indicated month.

Frequently asked questions

What do I do if I forget to take my tablet?

If you remember within 4 hours of the due time, then you should take your tablets straight away as directed by your doctor. If it’s been more than 4 hours, please call your doctor. Do not double up on your tablets to make up for missed doses.

What do I do if I accidentally overdose on my tablets?

Seek immediate medical attention or call the Poison Control Helpline. Initial symptoms of overdose may include drowsiness, dizziness, fits, and convulsions.

What do I do if I want to stop taking the medication?

Only stop taking your medication if you are told to do so by your doctor. The doctor would usually advise on how to taper down the dose, so that you do not feel any unpleasant withdrawal effects.

Where can I buy Zytram?

You can buy Zytram from with a valid prescription.

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