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Product Information

What is Rythmol?

Rythmol is the trade name of a prescription drug containing propafenone as the active component. Rythmol belongs to a class of heart medications called antiarrhythmic (certain types of irregular heartbeats) used to prolong recurrence time of atrial fibrillation (symptomatic) in patients who suffer from episodic persistent or paroxysmal atrial fibrillation and who do not have any structural heart disease. It is available as an immediate release tablet and as an extended release drug in different strengths of 150mg, 300mg (immediate release), and 225mg, 325mg, and 42mg (extended release). It was first approved by the Food and Drug Administration (FDA) in 1989 and is manufactured by GlaxoSmithKline.

Active ingredient

Propafenone is the active component of Rythmol, which has a stabilizing effect on the myocardium membrane and local aesthetic effect. It is used in patients with irregular heartbeats. Rythmol works by reducing the amount of sodium reaching the cells of the cardiac muscles, thereby causing a reduction in the rate at which the cells become excited leading to regulation of heartbeats.

Conditions treated

• Rapid or irregular heartbeats (arrhythmias)

Generic vs brand name

There is a generic version of Rythmol called propafenone. The generic is as effective as the brand name.

Dosage information

Use your medication as directed by your healthcare professional. If you are not sure of how to, please check with your doctor.

• The dosage has to be individualized for each patient based on their requirements, tolerance, general condition, response, and cardiovascular status.
• It is normally taken from 2 to 3 times a day to maintain its plasma concentrations.

Side effects

Rythmol may exhibit some side effects, which include, but are not limited to the list below. Report any new experience or feeling occurring after the use of Rythmol.

• Dizziness
• Palpitations
• Chest pain
• Dyspnea
• Taste disturbance
• Nausea
• Fatigue
• Anxiety
• Constipation
• Upper respiratory tract infection
• Edema
• Influenza
• Weakness

Contraindications

• The use of Rythmol is contraindicated in patients who are hypersensitive to propafenone or any of the excipients used in the formulation.
• The use of propafenone is contraindicated in patients who suffer from heart failure and cardiogenic shock.
• Use of propafenone is also contraindicated in intraventricular, atrioventricular, and sinoatrial disorders that conduct and/or generate impulses in the absence of a pacemaker.
• Use of propafenone is contraindicated in patients with known bradycardia, diagnosed hypotension, electrolyte imbalance, and severe obstructive pulmonary disease.

Precautions

Always remember to inform your doctor of any allergies or medical condition you may have, medications you are currently taking, if you are breastfeeding or pregnant, and any other important health conditions you might have.

Do not take Rythmol without consulting a doctor.

• The use of propafenone may worsen or cause new arrhythmias, therefore patients should be evaluated before and during therapy.
• The use of propafenone may unmask Brugada syndrome, patients should be evaluated via ECGs after starting therapy.
• Concurrent use of propafenone with other antiarrhythmic drugs or agents that may pro QT interval, cytochrome P450 2D6, and 3A4 inhibitors should be avoided.
• Use of propafenone may cause/provoke overt heart failure.
• Pacemakers should be monitored when propafenone is used
• Propafenone should not be given to patients with conduction defects without a pace maker.
• Propafenone should be use with caution in patients with renal and hepatic dysfunctions.

Drug interactions

Taking Rythmol with certain drugs can either potentiate their effects in the body or nullify them. Therefore, you should know the medicines you take and always remember to tell your healthcare provider when you are prescribed new medicine.

• Digoxin
• Warfarin
• Orlistat
• Lidocaine
• Cyclosporine
• Amiodarone
• Cimetidine
• Erythromycin

Frequently asked questions

How to store Rythmol?

• Store away from direct sunlight and heat.
• Store at room temperature.
• Do not store in a humid place (bathroom).
• Keep in a closed container.
• Keep out of the reach of children.

What if I overdose on Rythmol?

If you accidentally overdose on Rythmol, seek immediate medical advice or call the Poison Control Helpline at 1-800-222-1222. Symptoms may include very slow heartbeat, severe dizziness, new irregular heartbeat, and fainting.

What if I miss a dose of Rythmol?

Take a dose as soon as you remember; however, if you remember shortly before the next dose, only take one dose. Never double up on the doses.