Tri-cyclen Lo 28
Our best price: $27.14 USD per pack
*Maximum: 90-day supply  Maximum 90-day supply
Please note:

Due to policy restrictions and health regulations, can only dispense a maximum 90-day (3 month) supply of your medication based on a valid prescription. A valid prescription must be written and signed by a licensed physician and must have a prescription date that is no more than one year (365 days) old. All new prescriptions are verified with a signing physician.

If you place an order that exceeds a 90-day (3 month) supply of your medication, YouDrugstore will adjust your order to conform to policy restrictions. This adjustment will be confirmed with you before your order is processed.

This product is out of stock, please visit us later
Product type:
Active Ingredient(s):
norgestimate/ethinyl estradiol
Pack Size:
28 tablet(s)
Tri-cyclen Lo 28
Janssen Pharmaceuticals

How to order

You can order online from YouDrugstore. We are an online pharmacy based out of Canada. That means when you order from us, you pay the same price that most Canadians pay. All you have to do is register on our website and fill in all of the required information. Then send us your prescription so that our team of licensed pharmacy technicians and physicians can review your order once we have received all of the necessary information. When you order this medicine from YouDrugstore, enjoy our low cost in shipping. We even offer free shipping on any order over $100. Order from YouDrugstore today.

Information About Tri-Cyclen Lo

Tri-Cyclen Lo is an oral contraceptive containing ethinyl estradiol and norgestimate. It is designed to prevent unplanned pregnancies. This oral contraceptive is supplied in a pouch that contains a blister card of 28 coated tablets. Tri-Cyclen Lo is developed and manufactured by Janssen Ortho LLC.  This formulation has been approved by Food and Drug Administration (FDA) and is a prescription medication.

Active ingredients

Tri-Cyclen Lo contains the hormones norgestimate and ethinyl estradiol as its active ingredients. Norgestimate is a progesterone that helps to regulate menstruation and ovulation. Having high estrogenic potency, ethinyl estradiol is known to demonstrate agonist activities at estrogen receptors. The hormones work synergistically to inhibit ovulation, thereby preventing unintended pregnancy.

Conditions treated

Tri-Cyclen Lo is indicated for prevention of unintended pregnancy.

Dosage information

You can choose to start the treatment on Sunday or the first day of your period (day-1). Continue to take the pills every day for 21 days consecutively. You should take Tri-Cyclen Lo tablets at the same time every day. After 21 days, take the reminder pills (which are dark green in color) for 7 days in a row. You should begin the next pack on the day after the last reminder pill is taken.

Alternatively, you may begin taking the oral contraceptive on Sunday. Take the first active pill on the first Sunday after your period begins. During the first 7 days of treatment, you should use extra contraception (non-hormonal birth control such as spermicide and condoms) to reduce the risk of unwanted pregnancy. Take the active pills once a day for 21 days consecutively. Then, take the placebo tablets for the next 7 days. You should begin the next pack on the Sunday after the last placebo tablet is taken.

Tri-Cyclen Lo (norgestimate/ethinyl estradiol) is available in the dosage strengths of 0.180 mg/0.025mg, 0.215mg/0.025mg and 0.250mg/0.025mg.

Side effects

The common adverse effects of Tri-Cyclen Lo are as follows.

  • Breast tenderness
  • Nausea and vomiting
  • Nervousness, dizziness, or headache

Apart from that, this oral contraceptive pill may result in the following side effects.

  • Signs and symptoms of a blood clot in the leg e.g. swelling, pain, redness (unilateral or bilateral) and warmth.
  • Signs and symptoms of a lung blood clot, which include sudden cough, chest pain, rapid breathing, coughing up blood, and wheezing.
  • Signs and symptoms of stroke, including sudden severe headache, sudden weakness or numbness (especially unilaterally), problems with balance or vision, and slurred speech.

If you experience any of the symptoms listed above, you should stop using Tri-Cyclen Lo and see a doctor immediately.

This is by no means an exhaustive list of all the potential side effects of Tri-Cyclen Lo. The oral contraceptive may cause side effects that are not listed in this section. Do not be alarmed by this list, as you may not get any of the adverse reactions. Speak with your doctor if you have any questions about the side effects of Tri-Cyclen Lo.

Warnings and precautions

Refer to the sections below for more information on special warnings and precautions related to Tri-Cyclen Lo.


Tri-Cyclen Lo is contraindicated in:

  • Patients with a high risk of venous or arterial thrombotic diseases. This includes female smokers who are more than 35 years of age and those who have hypercoagulopathy (acquired or inherited), coronary artery disease, cerebrovascular disease, uncontrolled hypertension, thrombogenic rhythm heart diseases, migraine headaches with aura, headaches with focal neurological symptoms, diabetes mellitus with vascular disease or pulmonary embolism/deep vein thrombosis.
  • Concurrent use of Hepatitis C drug combinations (consist of ritonavir, ombitasvir or paritaprevir with/without dasabuvir)
  • Unusual uterine bleeding 


Tri-Cyclen Lo is known to increase the risk of severe cardiovascular events in females over 35 years of age who currently smoke. This includes heart attack, stroke, and blood clots. Do not use if you are affected.

Keep in mind that these oral contraceptive pills do not provide protection against sexually transmitted infections (STIs) or HIV infections (AIDS).

You should stop taking Tri-Cyclen Lo prior to a medical test or surgery. Tell your surgeon or doctor that you are currently on Tri-Cyclen Lo.

Drug interactions

  • Medications used to treat epilepsy including phenylbutazone (Butazolidin), phenytoin (Dilantin), barbiturates (e.g. phenobarbital), carbamazepine (Tegretol) and topiramate (Topamax)
  • Rifampin
  • Certain antibiotics
  • Anticonvulsants such as lamotrigine (Lamictal)
  • Some HIV/AIDS medications
  • St. John’s Wort
  • Drugs indicated for pulmonary hypertension such as bosentan (Tracleer)

Frequently asked questions

How does Tri-Cyclen Lo work?

Tri-Cyclen Lo is formulated with both norgestimate and ethinyl estradiol. Having ovulation-suppressing properties, norgestimate and ethinyl estradiol help to prevent unplanned pregnancy in female patients. The hormones also exert their contraceptive actions through other mechanisms. For example, they alter the cervical mucus to prevent the penetration of sperm. At the same time, ethinyl estradiol and norgestimate trigger changes in the endometrium to impede implantation.

How to store it

Keep Tri-Cyclen Lo pills at a room temperature between 68°F and 77°F (or 20°C and 25°C). Avoid exposure to light. As with all medications, keep out of reach of children.

Is there an alternative generic brand to Tri-Cyclen Lo?

A generic alternative of Tri-Cyclen Lo is available as norgestimate/ethinyl estradiol.

What if I overdose on Tri-Cyclen Lo?

An overdose of Tri-Cyclen Lo is unlikely to cause any severe complications. However, you may experience nausea or withdrawal bleeding if you ingest too many tablets. As a precaution, you should seek medical attention immediately if you overdose on Tri-Cyclen Lo. Go to the nearest hospital or call the local Poison Information Center.

What if I miss a dose of Tri-Cyclen Lo?

Take this medication regularly to ensure its effectiveness. A missed dose will increase the risk of becoming pregnant. If you forget to take 1 active tablet, you may need to take 2 tablets on the same day. Then resume the once daily regimen for the remainder of the pack. If you forget to take 2 active tablets in a row in week 1/week 2, use 2 tablets daily for 2 consecutive days. Then resume the normal dosing regimen for the remainder of the pills. You should use backup contraception for at least 1 week after a missed dose. If 2 active tablets are missed in week 3, discard the remainder of the pack and use a new pack on that day. This applies to day-1 starter. Sunday starters should continue to take a tablet every day until Sunday, then dispose of the remainder of the pack and use a new pack on the same Sunday. If more than 2 tablets are missed, you may not menstruate that month. If you do not get a period for 2 months consecutively, contact the doctor immediately to determine if you are pregnant.

You May Also Like...