Zoloft 100 mg
100 mg
Pack Size:
30 capsule(s)
Pfizer Inc.
*Maximum: 90-day supply  Maximum 90-day supply
Please note:

Due to policy restrictions and health regulations, can only dispense a maximum 90-day (3 month) supply of your medication based on a valid prescription. A valid prescription must be written and signed by a licensed physician and must have a prescription date that is no more than one year (365 days) old. All new prescriptions are verified with a signing physician.

If you place an order that exceeds a 90-day (3 month) supply of your medication, YouDrugstore will adjust your order to conform to policy restrictions. This adjustment will be confirmed with you before your order is processed.

Price per pack
$97.55 USD
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USD$79.81 79.81USD


Buy Zoloft (Sertraline) 100 mg Online  

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General Information About Zoloft

Zoloft is a well trusted and widely used antidepressant. The active ingredient in Zoloft is Sertraline; an antidepressant drug compound in a group of drugs known as selective serotonin reuptake inhibitors (SSRIs). Besides depression, Sertraline is used to treat obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Sertaline is manufactured by Pfizer under the brand name Zoloft. Sertraline was approved by the FDA in 1991 on the grounds of a recommendation by the Psychopharmacological Drugs Advisory Committee while the drug had already become available in the United Kingdom the previous year.

Active Ingredient

The active ingredient of Zoloft, Sertaline hydrochloride, acts as an effective serotonin reuptake inhibitor (SRI). Sertraline hydrochloride carries a total molecular weight of 342.7 and has the chemical name; (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride. Sertraline hydrochloride is a white crystalline powder that is fairly soluble in water and isopropyl alcohol, and thinly soluble in ethanol.

Through preventing the reuptake of serotonin, sertraline increases the levels of serotonin outside of the cells of the body and thereby increases serotonergic neurotransmission in the brain. This action is thought to be primarily responsible for the antidepressant, anxiolytic, and anti-obsessional effects of the compound, sertraline.

Indications and Uses 

Sertraline is used for a number of conditions. The most common conditions that may indicate the requirement for Zoloft include, but may not be limited to:

  • major depressive disorder (MDD) 
  • Obsessive–compulsive disorder (OCD)
  • body dysmorphic disorder (BDD)
  • posttraumatic stress disorder (PTSD)
  • premenstrual dysphoric disorder (PMDD)
  • panic disorder
  • social anxiety disorder (SAD)

Zoloft has also been prescribed to treat premature ejaculation as well as vascular headaches.

Sertraline Generic and Brand Names

Sertraline generic is currently manufactured by 66 companies. There are approximately over 115 Brands of Sertraline generics listed with new generics continually being updated. Besides Zoloft by Pfizer, some common sertraline 100mg generic brands.


Dosage Information: How Should I Take Zoloft?

Zoloft should be taken exactly as prescribed and instructed by your doctor. Do not take in higher or lower doses or for longer than recommended by your doctor. The doses directions on the prescription label should be followed exactly. Your doctor may sometimes alter your dose to ensure that you get the best results from the medication.

Sertraline can be taken with or without food. The medicine should ideally be taken at the same time each day. The directions on your prescription label should provide a reliable guideline for dosage and directions.

Sertraline is available in liquid form. This formula must be diluted before it is taken. To ensure that you take the correct dose, the liquid should be measured with the medicine dropper provided. Combine the dose with 4 ounces, that is; one-half cup, of water, ginger ale, lemon/lime soda, lemonade, or orange juice. Any other liquids should not be used to dilute the medicine. The mixture should then be stirred and the whole dose should be drunk right away. To ensure that you get the entire dose, a little more water can be added to the same glass, swirled gently and drunk right away.

Symptoms may take up to 4 weeks before beginning to improve or alleviate. It is important not to stop using sertraline without first talking to your doctor. It is common to experience unpleasant side effects if the medication is stopped taking abruptly.

Sertraline should be stored at room temperature and away from moisture and heat.

Side Effects

Medical advice should be sought immediately if you experience any of the following signs of an allergic reaction: 

  • Sudden skin rash or hives
  • Having difficulty breathing
  • Swelling of the face, lips, tongue, or throat.

New, unusual or worsening symptoms should be reported to your doctor as soon as possible. Symptoms may include:

  • Mood or behavior changes
  • Anxiety
  • Panic attacks
  • Trouble sleeping
  • Feeling impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

You should contact your doctor immediately if you present with any of the following serious side effect:

  • Hard or rigid muscles
  • Fever, sweating profusely, confusion or disorientation, rapid or uneven heartbeat, feeling faint or like you might lose consciousness
  • Agitation, hallucinations, fever, intense reflexes or tremors;
  • Feeling nauseated, vomiting, having diarrhea, losing appetite, feeling like you may fall over or loss of coordination
  • Headache, having trouble with concentration, problems with memory, feeling weak, fainting, seizures or convulsions, breathing that is shallow or that stops.

Other minor side effects:

  • Feeling drowsy, dizzy or tired
  • Being mildly nauseated, abdominal pain, or constipation
  • Having a dry mouth
  • Sudden weight or appetite changes
  • Problems with sleep such as insomnia
  • Decreased libido, impotence, or suddenly having difficulty reaching an orgasm.

Warnings and Precautions

It is possible to experience suicidal thoughts when you initially start taking antidepressant medications. This is is especially true if at the time you start taking them, you are younger than 24 years of age. It may be necessary for your doctor to check you at regular visits, at least for the first 12 weeks of treatment.

You should promptly inform your doctor if you experience any new or worsening symptoms while on sertraline. These symptoms may include but are not limited to: mood or behavior changes, anxiety, panic attacks, having trouble sleeping, or feelings of being impulsive, irritability, agitation, hostility, aggression, restlessness, hyperactivity (mentally or physically), feeling more depressed, or having thoughts about suicide or harming yourself.

Pregnancy is contraindicated for sertraline and should therefore be promptly reported to your doctor while on sertraline. It can cause heart defects and/or severe lung problems in newborn babies if taken during pregnancy. It is possible, however, to relapse into depression once you discontinue the antidepressant. It is important not to start or discontinue sertraline in pregnancy at your own discretion, without a doctor's advice.

It is not clear whether or not sertraline passes into breast milk or if it could potentially harm a nursing baby. if you are breast-feeding a baby, it is important that you do not use this medication without notifying your doctor.

To ensure that you it is safe for you to take sertraline, it is important to notify the doctor if you know that you have any of the following conditions:

  • Kidney disease or liver disease
  • Seizures/convulsions or epilepsy
  • Bleeding disorder or blood clotting disorder
  • Bipolar disorder
  • A history of or any latent drug abuse or thoughts of suicide.
  • Alcohol can increase some side effects of sertraline.

If you are taking disulfiram (Antabuse), do not take the liquid form of sertraline. Liquid sertraline might contain alcohol and cause you to have a severe reaction to the disulfiram.

Although sertraline is approved by the FDA for children with obsessive-compulsive disorder (OCD), it is not approved for treating depression in children and should not be given sertraline to anyone younger than 18 years old without the explicit advice of a doctor.

Sertraline can cause an drug screening tests to come up with a false positive result. If you submit a urine sample for drug screening, you should notify laboratory staff of the fact that you are taking sertraline.

Which drugs interact with Zoloft?

Sertraline should not be taken if in the last 14days, you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Taking sertraline in conjunction with or within less than 14-day period can cause a dangerous drug interaction to occur and lead to serious side effects. You must allow, at the least, 14 days passing after discontinuing an MAO inhibitor before taking sertraline. After discontinuing sertraline, at least 14 days should pass before you start taking an MAOI.

Using NSAID medications while taking sertraline may cause you to bruise or bleed much more easily than usual. These medications are usually taken for pain, arthritis, fever, or swelling and you may need to seek your doctor’s advice before taking them. NSAID medications include but are not limited to: Asprin, Ibuprofen, naproxen, meloxicam, diclofenac, celecoxib, or indomethacin.

 Inform your doctor prior to taking sertraline if you frequently use medicines that induce sleepiness, including but not limited to: cough medicine or allergy medicine, sedative medications, pain medicine (narcotic), sleeping pills, muscle relaxants, and seizure/convulsion or anxiety medications. These medications may further exacerbate sleepiness caused by sertraline.

Inform the doctor about other medicines you may be using, especially if any of the following:

  • cimetidine
  • fentanyl
  • Digitoxin
  • linezolid
  • St. John’s wort
  • Lithium
  • tramadol (Ultram, Ultram ER, Ultracet)
  • 5-hydroxytryptophan (5-HTP)
  • Cold and cough medications
  • Blood thinning medications such as warfarin (Coumadin, Jantoven)
  • valproate
  • Antidepressant, including but not limited to; amitriptyline (Elavil), bupropion(Wellbutrin), desvenlafaxine (Pristiq), duloxetine(Cymbalta), citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), imipramine (Tofranil), milnacipran (Savella), sertraline, nortriptyline (Pamelor), paroxetine (Paxil), or venlafaxine (Effexor)
  • Heart rythm regulatory medications including, but not limited to, flecainide (Tambocor), propafenone (Rhythmol), among others
  • Migraine headache medication including but not limited to, lmotriptan (Axert), eletriptan(Relpax),naratriptan (Amerge),  frovatriptan (Frova), rizatriptan (Maxalt), sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig).

The list of medications that can interact with Sertraline is incomplete. Other drugs or supplements may possibly interact with sertraline. Inform the doctor about any and all medications that you are using, including prescription drugs, over-the-counter medications, vitamin and supplements, as well as herbal products. Always inform and seek the advice of your doctor before starting any new medication.

Frequently Asked Questions About Zoloft

What is Zoloft?

Sertraline is a selective serotonin reuptake inhibitors (SSRIs) antidepressant drug. It is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

How does Zoloft work?

Sertraline performs as an effective serotonin reuptake inhibitor (SRI). It is very selective in its inhibition of serotonin reuptake. Inhibiting the reuptake of serotonin allows sertraline to increase extracellular levels of serotonin and thus increases serotonergic neurotransmission in the brain. The effect of this action is responsible for the antidepressant, anxiolytic, and anti-obsessional properties of sertraline.

How to store Zoloft?

Sertraline should be stored at room temperature and should be kept away from moisture and heat.

What is Major Depressive Disorder (MDD)?

Major depressive disorder (MDD), also known as depression, is a mental disorder that is characterized by, at the very least, two weeks of persistent low mood that is present across most situations and/or circumstances.

Is Zoloft called differently in Canada than the USA?

Sertraline is marketed in the USA and Canada by Pfizer under the trade/brand name Zoloft.

How and when to take it?

Zoloft should be taken exactly as prescribed and directed by your doctor. The doctor may modify your dosage at said intervals until a recommended dosage peak is reached, after which the dosage will be maintained for the duration of your course.

Why do doctors prescribe it?

Doctors may prescribe sertraline for the treatment of depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

What if I overdose?

You have to seek emergency medical care or call the Poison Help line at 1-800-222-1222 if you overdose on this sertraline. Symptoms of overdose may include extreme drowsiness, vomiting, rapid heart rate, agitation, and/or tremor.

What if I miss a dose?

The missed dose should be taken as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

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