Buy Anafranil (Clomipramine) 10/25/50 Mg Online | Low Cost
Anafranil 10 mg
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Product type:
Active Ingredient(s):
10 mg
Pack Size:
100 tablet(s)
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Buy Anafranil (Clomipramine) 10, 25, 50 mg Online  

Other strengths

What is Anafranil (Clomipramine)?

Anafranil is the trade name of a prescription drug containing clomipramine hydrochloride (clomipramine) as the active component. Clomipramine belongs to group of drug called dibenzazepine and it is a tricyclic antidepressant used to treat obsession, phobias (irrational fears) and depression, it is also sometimes used in the treatment of muscular weakness associated with sleepiness. The drug is manufactured by Mallinckrodt LLC and was first approved by the FDA in 1989.

How does it work?

Anafranil is believed to work by interfering with serotonin’s (chemical in the brain) reuptake inhibition in the brain.

What is Anafranil used for?

  1. Obsessive Compulsive Disorder (OCD)
  2. Phobias (irrational fears)
  3. Depression.

Active Ingredient

The actual mechanism of how clomipramine functions in treating depression, OCD and phobias is unknown. However it is thought to function by inhibiting the reuptake of serotonin (a chemical in the brain) hence stabilizing the patients.

Generic Alternatives

There are a few generic brands for the oral tablets of Anafranil. The generics are very much effective as the originator. Generic medications include Clomipramine.

Indications and Dosage Information

Note: Your doctor may be required to prescribe doses that differ from the recommended dosages, do not change your dose or take the medication contrary to the doctor’s directions.

  • Adults: The recommended starting dose is 25 mg per day, this dose can gradually be increased to a well-tolerated dose of 100 mg within the first two weeks. Subsequently the dose can be increased to a maximum daily dose of 250 mg per day.
  • Children and Adolescents: same as with adults, the recommended starting dose is 25 mg per day and can be gradually increased to a well-tolerated dose of 100 mg or 3 mg/kg during the first two weeks and subsequently increased over the next few weeks to a max dose of 200 mg or 3 mg/kg per day.

Note: During the initial phase of titration, Anafranil should be used in divided doses and after titration, the total daily dose should be given at night.

  • This medication should be taken with food to avoid gastrointestinal side effects.

Clomipramine side effects

Anafranil like all other drugs may exhibit some side effects, these may range from mild (normally disappear) to severe (stop its use when the severe cases appear). Below is a list of some side affects you may experience with the use of this medication.

Note: this may not be a complete list therefore you should report any new experience or feeling occurring after the use of Clomipramine.

  • Rash
  • Changes in blood pressure
  • Swelling
  • Increased fluid in tissues
  • Increase in heart rate
  • Difficulty with breathing
  • Confusion
  • Headaches
  • Dizziness
  • Nausea
  • Constipation
  • Dry mouth
  • Increased sweating
  • Shaking hands
  • Tremor
  • Difficulty in passing urine
  • Feeling tired or sleepy
  • Sexual disturbances

Warnings and Precautions


  • The use of Anafranil is contraindicated in patients who are hypersensitive to Anafranil or other tricyclic antidepressants.
  • The concurrent use of Anafranil with MAOIs intended for the treatment of psychiatric problems or within 14 days of stopping use of Anafranil is contraindicated due to the increase risk of serotonin syndrome and vice versa.
  • Do not use Clomipramine in patients currently been treated with intravenous methylene blue and linezolid, it could lead to an increase risk of serotonin syndrome.
  • This drug is also contraindicated during a recovery period (acute) of myocardial infarction.


  • Monitor patients for suicide risk and clinical worsening.
  • Screen patients for bipolar Disorder
  • Serotonin Syndrome: this has been reported in fluvoxamine, SNRIs and SSRIs alone and most often when administered with other serotonergic including the following tramadol, tryptophan, lithium, tricyclic antidepressants, fentanyl, St. John's Wort, buspirone, and triptans. Patients should be made aware of the potential risk of serotonin syndrome at start of treatment and dose increase.
  • Anafranil should be used with caution in patients with liver problems.
  • The use of Clomipramine has been associated with hematological changes such as thrombocytopenia, agranulocytosis, leukopenia, anemia, and pancytopenia.
  • Surgery before undergoing any elective surgery, the use of Anafranil should be discontinued for as the duration of treatment/recovery.
  • The drug should be used with caution in hyperthyroid patients and patients that are or receiving thyroid medications, so as to reduce the risk of cardiac toxicity.
  • Clomipramine should be used with caution in patients with impaired renal function.

Drug Interactions

Taking Anafranil with certain drugs can either potentiate their effects in the body or nullify them, it may affect the manner in which these drugs work or vice versa. Therefore you should know the medicines you take and always remember to tell your healthcare provider and pharmacist when you are prescribed new medicine. Below are examples of medicines that may interact Anafranil when used together.

  • Guanethidine
  • Clonidine
  • Haloperidol
  • Cimetidine,
  • Fluoxetine
  • Phenytoin
  • warfarin
  • digoxin
  • Quinidine
  • Monoamine Oxidase Inhibitors (MAOIs) e.g. phenelzine, tranylcypromine, etc
  • Serotonergic Drugs e.g. paroxetine, sertraline, fluvoxamine.
  • Blood pressure medications
  • Water tablets
  • Carbamazepine
  • Ritonavir
  • Indinavir

How to store it.

  • Store away from direct sunlight and heat.
  • Store at room temperature between 15˚C-30˚C.
  • Do not store in a humid place (bathroom).
  • Keep in a well closed container.
  • Keep out of the reach of children.

What if I overdose on it?

If you accidentally overdose on Anafranil, seek immediate medical advice or call the Poison Helpline at 1-800-222-1222.

Symptoms of over dose include: vomiting, nausea hypokalemia, diarrhea, hypotension, tachycardia, somnolence and respiratory difficulties.

Antidote: Clomipramine does not have any specific antidote however in cases of overdose, the stomach most be emptied as soon as possible, administer activated charcoal repeatedly if necessary.

What if I miss a dose?

Take a dose as soon as you remember, however if you remember just an hour or two before the next dose, only take one dose. Never try to double up on the doses.

How to buy this drug safely online ?

Buy it from us. YouDrugstore is a licensed online pharmacy, based in Canada, where you can buy medications for the same price most Canadians pay. Register on our website and fill in all of the relevant information. After that, send us your prescription so that our licensed physicians and pharmacy technicians can review your order. You can even speed up the process by asking your doctor to fax us your prescription directly from their office. When you order from YouDrugstore, we will ship your genuine medication right to your home for a cheap cost in shipping. In fact, YouDrugstore offers free shipping on any order over $100. Order today and start saving!