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Latuda 40 mg
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Product type:
Active Ingredient(s):
40 mg
Pack Size:
30 tablet(s)
Latuda 40mg 30 Tablets (Rx-B-Dry-CAD)
Sunovion Pharmaceuticals
Country of Origin:



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General Information About Latuda

Latuda is an innovative antipsychotic drug that is commonly prescribed for the treatment of psychiatric disorders such as schizophrenia and bipolar disorder. The drug has been reported to improve the appetite, mood and sleep disturbance associated with psychiatric disorders. Latuda is being manufactured by Sunovion Pharmaceuticals which is a subsidiary of Dainippon Sumitomo Pharma Co. Ltd. The drug was approved for marketing by the FDA in the year 2010.

Active ingredient

Latuda contains Lurasidone as its active component which belongs to the class of atypical antipsychotics. Lurasidone is a second generation antipsychotic that acts as an antagonist at the dopamine D2 and serotonin (5HT2A) receptors. The drug also exerts partial agonist activity at the 5HT1A receptors and antagonist activity at the 5HT7 receptors1. Lurasidone also has moderate level of antagonistic activity at alpha2C- and alpha2A-adrenergic receptors2.

Conditions treated by Latuda

The drug has been approved by the FDA for the treatment of


Bipolar I Disorder (depressive episodes) as monotherapy or as an adjunct along with Lithium and Valproate (Valproic Acid)

Dosage information

Latuda comes in a packet containing 30, white to off-white colored, tablets to be taken orally. The drug should be taken along with food (ideally at least 350 calories of food). Avoid alcohol ingestion along with the drug. The drug should always be taken upon doctor’s advice. The recommended dosage of Latuda is as follows.

Schizophrenia: 40 mg per day. Can be increased up to 160mg per day.

Bipolar depressive disorder: 20mg per day. Can be increased up to 120mg per day.

Side effects

The common side effects of Latuda include

  • Somnolence (increased sleepiness)
  • Akathisia (excessive feeling of restlessness)
  • Nausea & vomiting
  • Anxiety
  • Extrapyramidal symptoms (muscle stiffness, slow movements, tremors etc.)

Serious side effects of Latuda include

  • Neuroleptic malignant syndrome (NMS): A rare but life-threatening condition characterized by high grade fever, excessive sweating, muscle rigidity, agitation, confusion, increased respiratory rate, accelerated heart beat and irregular pulse3.
  • Tardive dyskinesia: Involuntary, repetitive body movements such as grimacing or sticking out the tongue etc.
  • Seizures
  • Difficulty in swallowing
  • Orthostatic hypotension (drop in blood pressure upon posture change)
  • Syncope (loss of consciousness as a result of insufficient blood flow to brain)

Other adverse events associated with the use of Latuda include

  • Hyperglycemia (high blood sugar level)
  • Hyperlipidemia
  • Hypertriglyceridemia
  • Weight gain
  • Decreased white cell count
  • Increased prolactin levels
  • Impairment of judgment/thinking/motor skills

Warnings and Precautions

The following precautionary measures should be exercised while using Latuda.


Absolute contraindications of Latuda include:

  • Known hypersensitivity to Latuda
  • Concomitant use with a strong CYP3A4 inhibitor (e.g. Ketoconazole)
  • Concomitant use with a strong CYP3A4 inducer (e.g. Rifampin)
  • Dementia related psychosis


Latuda increases the mortality by cerebrovascular events, such as stroke or ischemia, in elderly patients suffering from dementia related psychosis which is why the drug should not be used in such patients 4.

Concomitant use of Latuda along with antidepressants in children, adolescents and young adults increases the risk of suicidal thinking. Therefore, the families and caregivers of patients receiving antidepressants concomitantly should be educated about close monitoring of the patients for even slight behavioral changes.

The use of Latuda in patients suffering from bipolar depression should be watched closely as it can trigger manic episodes in such patients.

Patients with moderate to severe renal impairment should be prescribed low doses of Latuda (ideally 20mg per day).

Patients with moderate to severe hepatic dysfunction should take low doses of Latuda and should exercise caution while using the drug.

Concomitant use of Latuda along with a moderate CYP3A4 inhibitor (e.g. Diltiazem) or with a moderate CYP3A4 inducer should be avoided as dosage changes may be required.

Patients on Latuda should avoid taking grapefruit and grapefruit juice.

Patients with diabetes mellitus should closely monitor their blood glucose levels for hyperglycemia.

Patients with history of seizures should be given Latuda quite cautiously.

Latuda can cause increase in the body temperature. Therefore, patients taking Latuda should avoid intense workouts and exposure to high temperature.

Latuda is a category B drug and should be used in pregnant women only if its advantages outweigh the potential risks.

Latuda is not approved for use in children.

Drug interactions

  • Strong CYP3A4 inhibitors: Ketoconazole, Clarithromycin, Ritonavir, Voriconazole etc.
  • Moderate CYP3A4 inhibitors: Diltiazem, Atazanavir, Erythromycin, Fluconazole etc.
  • Strong CYP3A4 inducers: Rifampin, Carbamazepine, etc.
  • Moderate CYP3A4 inducers
  • Lithium
  • Valproate
  • Grapefruit juice

Frequently Asked Questions

What is Latuda?

Latuda is a novel antipsychotic drug that is commonly prescribed for the treatment of Schizophrenia and Bipolar depression.

How does Latuda work?

Latuda contains Lurasidone which acts as an antagonist at the dopamine D2 and serotonin (5HT2A) receptors. The drug also has partial 5HT1A agonistic, 5HT7 antagonistic and moderate alpha2C- and alpha2A-adrenergic antagonistic activity.

How to store it?

Latuda should be stored at room temperature between 15oC and 30oC. Store the drug away from heat, moisture and direct light sources, out of reach of children.

Where can I buy Latuda?

Latuda is available at Youdrugstore as oral formulation in packs containing 30 tablets.

Is there any alternative generic brand to Latuda?

There is no alternative to Latuda.

How and when to take Latuda?

The recommended dose of Latuda is one tablet daily (40mg per day) for Schizophrenia whereas for Bipolar Depression, it is half a tablet per day (20mg daily). The doctor can increase the dose of the drug if needed. The drug should always be taken upon doctor’s advice exactly as prescribed by the doctor. Do not increase or decrease the dose of the drug by yourself. Take Latuda 40mf with food (at least 350 calories). Swallow the tablet with small amount of water as a whole and avoid chewing it. Avoid alcohol consumption along with Latuda intake.

Why do doctors prescribe Latuda?

Latuda is commonly prescribed for the treatment of schizophrenia and bipolar depression.

What is schizophrenia?

Schizophrenia is a chronic, severe psychiatric disorder characterized by hallucinations, delusions, thought disorder and movement disorders. The symptoms include apathy, less engagement in pleasure activities, difficulty in beginning and carrying out activities, decreased focusing or attention and problems with working memory etc.

What is bipolar depression?

Also known as manic-depressive disorder, bipolar disorder is a psychiatric illness that is characterized by episodes of mania and depression. Bipolar depression is a part of bipolar disorder and pertains to periods of depressed mood with sleep and appetite changes that alternate with periods of normal mood and maniac episodes.

What if I overdose on Latuda?

If you accidentally overdose on Latuda, report to the nearest medical facility, call your healthcare provider or call the Poison Control Center at 1-800-222-1222 right away.

What if I miss a dose of Latuda?

If you miss a dose of Latuda, take the missed dose as soon as you remember it. However, if the time of next dose is impending, do not take the missed dose to avoid over dosage of the drug. Call your doctor if you are not sure about the missed dose schedule.