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Latuda is an innovative antipsychotic drug that is commonly prescribed for the treatment of psychiatric disorders such as schizophrenia and bipolar disorder. The drug has been reported to improve the appetite, mood and sleep disturbance associated with psychiatric disorders. Latuda is being manufactured by Sunovion Pharmaceuticals which is a subsidiary of Dainippon Sumitomo Pharma Co. Ltd. The drug was approved for marketing by the FDA in the year 2010.
Latuda contains Lurasidone as its active component which belongs to the class of atypical antipsychotics. Lurasidone is a second generation antipsychotic that acts as an antagonist at the dopamine D2 and serotonin (5HT2A) receptors. The drug also exerts partial agonist activity at the 5HT1A receptors and antagonist activity at the 5HT7 receptors1. Lurasidone also has moderate level of antagonistic activity at alpha2C- and alpha2A-adrenergic receptors2.
The drug has been approved by the FDA for the treatment of
Latuda comes in a packet containing 30, white to off-white colored, tablets to be taken orally. The drug should be taken along with food (ideally at least 350 calories of food). Avoid alcohol ingestion along with the drug. The drug should always be taken upon doctor’s advice. The recommended dosage of Latuda is as follows.
Schizophrenia: 40 mg per day. Can be increased up to 160mg per day.
Bipolar depressive disorder: 20mg per day. Can be increased up to 120mg per day.
The common side effects of Latuda include
Serious side effects of Latuda include
Other adverse events associated with the use of Latuda include
The following precautionary measures should be exercised while using Latuda.
Absolute contraindications of Latuda include:
Latuda increases the mortality by cerebrovascular events, such as stroke or ischemia, in elderly patients suffering from dementia related psychosis which is why the drug should not be used in such patients 4.
Concomitant use of Latuda along with antidepressants in children, adolescents and young adults increases the risk of suicidal thinking. Therefore, the families and caregivers of patients receiving antidepressants concomitantly should be educated about close monitoring of the patients for even slight behavioral changes.
The use of Latuda in patients suffering from bipolar depression should be watched closely as it can trigger manic episodes in such patients.
Patients with moderate to severe renal impairment should be prescribed low doses of Latuda (ideally 20mg per day).
Patients with moderate to severe hepatic dysfunction should take low doses of Latuda and should exercise caution while using the drug.
Concomitant use of Latuda along with a moderate CYP3A4 inhibitor (e.g. Diltiazem) or with a moderate CYP3A4 inducer should be avoided as dosage changes may be required.
Patients on Latuda should avoid taking grapefruit and grapefruit juice.
Patients with diabetes mellitus should closely monitor their blood glucose levels for hyperglycemia.
Patients with history of seizures should be given Latuda quite cautiously.
Latuda can cause increase in the body temperature. Therefore, patients taking Latuda should avoid intense workouts and exposure to high temperature.
Latuda is a category B drug and should be used in pregnant women only if its advantages outweigh the potential risks.
Latuda is not approved for use in children.
Latuda is a novel antipsychotic drug that is commonly prescribed for the treatment of Schizophrenia and Bipolar depression.
Latuda contains Lurasidone which acts as an antagonist at the dopamine D2 and serotonin (5HT2A) receptors. The drug also has partial 5HT1A agonistic, 5HT7 antagonistic and moderate alpha2C- and alpha2A-adrenergic antagonistic activity.
Latuda should be stored at room temperature between 15oC and 30oC. Store the drug away from heat, moisture and direct light sources, out of reach of children.
Latuda is available at Youdrugstore as oral formulation in packs containing 30 tablets.
There is no alternative to Latuda.
The recommended dose of Latuda is one tablet daily (40mg per day) for Schizophrenia whereas for Bipolar Depression, it is half a tablet per day (20mg daily). The doctor can increase the dose of the drug if needed. The drug should always be taken upon doctor’s advice exactly as prescribed by the doctor. Do not increase or decrease the dose of the drug by yourself. Take Latuda 40mf with food (at least 350 calories). Swallow the tablet with small amount of water as a whole and avoid chewing it. Avoid alcohol consumption along with Latuda intake.
Latuda is commonly prescribed for the treatment of schizophrenia and bipolar depression.
Schizophrenia is a chronic, severe psychiatric disorder characterized by hallucinations, delusions, thought disorder and movement disorders. The symptoms include apathy, less engagement in pleasure activities, difficulty in beginning and carrying out activities, decreased focusing or attention and problems with working memory etc.
Also known as manic-depressive disorder, bipolar disorder is a psychiatric illness that is characterized by episodes of mania and depression. Bipolar depression is a part of bipolar disorder and pertains to periods of depressed mood with sleep and appetite changes that alternate with periods of normal mood and maniac episodes.
If you accidentally overdose on Latuda, report to the nearest medical facility, call your healthcare provider or call the Poison Control Center at 1-800-222-1222 right away.
If you miss a dose of Latuda, take the missed dose as soon as you remember it. However, if the time of next dose is impending, do not take the missed dose to avoid over dosage of the drug. Call your doctor if you are not sure about the missed dose schedule.
1. Citrome, Leslie. "Lurasidone for schizophrenia: a brief review of a new second-generation antipsychotic." Clinical schizophrenia & related psychoses 4.4 (2010): 251-257.
2. Cruz, Martin P. "Lurasidone HCl (Latuda), an oral, once-daily atypical antipsychotic agent for the treatment of patients with schizophrenia." Pharmacy and Therapeutics 36.8 (2011): 489.
3. Nakamura, Mitsutaka, et al. "Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial." Journal of Clinical Psychiatry 70.6 (2009): 829.
4. McEvoy, Joseph P., et al. "Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study." J Clin Psychiatry 74.2 (2013): 170-179.