Health And Wellness

Health And Wellness

Can Nortriptyline Get You High?

Can Nortriptyline Get You High?
Nortriptyline hydrochloride is a tricyclic antidepressant used to treat symptoms of major depression in adults. It is also being used off label for anxiety disorder, neuropathic pain, and nicotine addiction. It is contraindicated in pediatric and young adult patients due to risk of suicidal ideation. Aventyl and Pamelor are the common brand names of nortriptyline that is used to treat depressive symptoms. Both are supplied in a capsule (10mg, 25mg, 50mg, 75mg) and oral solution (5ml, 10ml) form. The availability of more recent generation of selective serotonin reuptake inhibitors (SSRI) causes a decline in prescribing tricyclic antidepressant, but with regard to endogenous depression or melancholic subtype, nortriptyline has higher success rates than SSRIs. How tricyclics work? This medication is a 2nd generation tricyclic antidepressant approved for the treatment of depression. The exact mechanism of action of tricyclic antidepressants is not yet fully understood. It is b ...

Is there a Generic Cialis?

Is there a Generic Cialis?
Cialis (tadalafil) belongs to the second generation of phosphodiesterase 5 (PDE5) inhibitors—a group of drugs that serves as a first-line treatment for erectile dysfunction in men (ED).  Tadalafil is also approved for the treatment of prostate enlargement. Eli Lilly and Company is the sole manufacturer of Cialis, but its patent is about to expire in September 2018. Losing exclusivity to their wonder drug means another company can manufacture a generic Cialis, which in return will cause a definite slide in sales. Branded drugs lose up to 90% of their earnings when generic versions are released in the market. The lifestyle drug Cialis, like Pfizer’s Viagra, is a PDE5 inhibitor, which naturally degrades cyclic guanosine monophosphate or cGMP. The erection-assisting property of PDE5 inhibitor drugs occurs within the spongy erectile tissue of the penis. The penis is maintained in a flaccid state until contraction of the cavernosal muscle and constriction of penile ar ...

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