To diurese or to anti-diurese—that is the question.
So begins a pair of articles about increasing or decreasing the amount of urine output. This first one will discuss anti-diuresis, or the inhibition of urinary output. This is done with drugs called antidiuretics, and to understand them, it is helpful to discuss nature’s way of doing the same thing with a hormone upon which the synthetic drugs are based.
What is Anti-diuretic hormone (ADH, or vasopressin)?
The posterior pituitary gland in your brain stores and releases anti-diuretic hormone (ADH, or vasopressin), which is made in the hypothalamus. This hormone decreases the amount of urine that is produced by your kidneys. At first, this sounds like the opposite of what is desirable, because urinating several times a day is a good indicator that all is well—your heart is pumping blood with enough healthy force to reach your kidneys and a good blood pressure there is obviously in effect. So directly it give ...
Viagra was an accident.
Sildenafil was a drug being investigated by Pfizer for treating blood pressure. It flunked the stringent FDA criteria to make the grade, but as the story goes, the men participating in the study began snickering about all the erections they were having. And the rest, as they say, is history.
What is Erectile Dysfunction (ED)?
Erectile dysfunction (ED)—formally called impotence—is a failure to have or maintain an erection, which is sexually crippling. Along with premature and other ejaculatory abnormalities, it is one of the categories of sexual dysfunction in men.
The penis normally has a mechanism by which engorgement with blood expands the flaccid, erectile tissues such that penetration in intercourse is possible. Erectile dysfunction—or, ED—affects up to 40% of men over 40 and 70% over 70.
What’s going on? Is it a mutation? A new type of zombie apocalypse?
Why is ED getting to be so common?