Health And Wellness

Health And Wellness

What is Nortriptyline 25mg Used For?

What is Nortriptyline 25mg Used For?
Nortriptyline 25mg is used to treat mental or mood problems such as depression. It is being marketed under the brand names Pamelor and Aventyl. This medication is a tricyclic antidepressant, specifically of dibenzocycloheptene type, and is the active metabolite of the tertiary amine‚ÄĒamitriptyline. Tricyclic antidepressants work by inhibiting the reabsorption of the biogenic amine neurotransmitters: norepinephrine (NE) and serotonin (5HT). Tertiary amines inhibit the reuptake of both neurotransmitters, but secondary amines like nortriptyline are more selective of inhibiting NE over 5HT. Tricyclic antidepressants (TCA) are rarely used as first-line or even second-line treatment for depression because of its extensive side effect profile and high overdose risk. However, it is still one of the most effective pharmacological therapies for severe depression or major depressive disorder of melancholic type, demonstrating greater efficacy over selective serotonin reuptake inh ...

Vaccines: Everything You Need to Know About HIV Vaccines

Vaccines: Everything You Need to Know About HIV Vaccines.
Vaccines Dutch scientist Antonie van Leeuwenhoek first saw bacteria through a microscope in 1676. 255 years later, viruses were first seen with the introduction of the electron microscope in 1931. The reason it took another quarter of a millennium to see viruses after bacteria is because of the size difference between them. Furthermore, visual identification was hampered by the limits of technology. The first antibiotic was developed in 1910 to treat syphilis, and in 1944, during WWII, mass production of penicillin began. It wasn’t until a generation later, however, that antiviral therapy came into clinical use. Again, size mattered. Bacteria are generally larger and have more parts to attack: cell membranes, organelles, etc. Viruses, although simpler, prove more difficult to attack, as they require attacks at the genetic level. The first antivirals: vaccines Vaccines were developed before the actual discovery of the virus. Doctors knew there was something m ...

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