Glucagon, Goldilocks, and the Three Bears
To understand the role of the medication, Glucagon, one must understand how it figures in the grand scheme of things, and it all starts with eating. In healthy people, eating causes1
the intestines release two chemicals (peptides), GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)—thank goodness for abbreviations!
the pancreas to release insulin and amylin.
The GLP-1 from the intestines and the amylin from the pancreas work together to:
inhibit stomach emptying, delaying food’s passing on into the intestines where sugar (glucose) is absorbed;
inhibit glucagon release (glucagon raises blood sugar);4
inhibit appetite (the “fed” signal to the brain).
The GLP-1 and the GIP from the intestines stimulate the secretion of insulin from the pancreas (called “the incretin effect”).
Therefore, a short su ...
What Is Voltaren?
Let's first define what Voltaren is. Voltaren is a medication containing diclofenac, an NSAID (nonsteroidal anti-inflammatory drug), and it is a non-inflamatory. Diclofenac is used commonly for inflammatory joint disease, such as rheumatoid and osteoarthritis.1 NSAIDs reduce substances in the body that cause pain and inflammation. 2 Diclofenac is classified as a COX-2 inhibitor, which specifically targets an enzyme involved in pain. There are side effects to taking NSAIDs orally, so topical preparations have been developed for site-specific application that delivers more of the medicine to an affected area while decreasing absorption into the rest of the body. It is more of a surgical strike of sorts.
With this strategy, the pharmaceutical industries are constantly trying to improve absorption, while increasing pain relief and decreasing the chances of side effects from systemic absorption.
What is Voltaren used for?
Diclofenac, the active ingredie ...