A funny thing happened on the way to treating diabetes—a welcome side effect became evident: weight loss. The medication, liraglutide, was originally approved in 20101 for assisting in the management of Type 2 diabetes. This was due to something called the incretin effect, which is an increase in insulin when glucose rises—something that is natural in most people but is faulty in diabetics. (Insulin is the body’s way of taking sugar into the system for the creation of energy or energy storage.) The normal incretin effect is caused by the body’s GLP-1 (glucagon-like peptide), which is the mechanism by which it helps control blood sugar. Liraglutide, which mimics the actions of GLP-1 (GLP-1 agonist), does the same thing, helping in the control of diabets.
GLP-1’s multitasking abilities
GLP-1, however, also serves as the body’s “fed” signal,2 which comes in handy before tackling the second half of that roast beef su ...
Victoza and Saxenda
What is Liraglutide?
Liraglutide is the generic name for two diabetes drugs, brand-named Victoza and Saxenda. The two drugs both contain this same ingredient, although they are FDA approved for different things. That is a dosage difference only.
Indications for Victoza 1—FDA indicated to help lower blood sugar levels in conjunction with diet, exercise, and other diabetes medicines. As such, it is not a first choice for diabetes II, but only for patients that need supplemental treatment to other diabetic medications. Although the higher dose Saxenda (see below) is the same medicine, but for weight loss, the lower-dosed Victoza has also been known to have weight loss as a side effect.
Indications for Saxenda2—FDA approved for weight loss. It also can be used for diabetes II, but since the dose for weight loss is higher than that of Victoza, it also helps with sugar control. It is approved for people with a body mass index (B ...